Current Issue : April - June Volume : 2016 Issue Number : 2 Articles : 4 Articles
Petasin is a potential anticancer agent against human neuroblastoma cell SK-N-SH by inhibiting the extracellular signal-regulated protein kinases 1 and 2 phosphorylation. Due to great activity and new anti-proliferative mechanisms, QSAR study was done on a series of petasin derivatives. 14 compounds were used for QSAR against SK-N-SH cell line by using pIC50 activity. Here the QSAR studies of petasin derivatives were performed by using software CHEM-DRAW ULTRA-8.0, OPENBABLE- 2.2.1, DRAGON and VALSTAT. Two model equations for the QSAR study were considered....
A series of N-substituted 2-chloro phenothiazine derived chloro compounds (3a-3c) and morpholine based compounds (5a-5c) has been synthesized. The molecular structures of synthesized compounds were confirmed by using various spectral techniques viz., FT-IR, 1H, 13C NMR and mass spectroscopy. The strong stretching vibrational bands in the region 1696- 1670 cm-1 in FT-IR spectral analysis confirms the presence of carbonyl moiety in the synthesized compounds. The presence of signals in the downfield region (4.2-3.5 Hz) of proton NMR of 5a-5c was due to methylene protons which confirm their formation. The antimicrobial investigations were carried out against one gram positive bacterial species such as Bacillus subtilis and three gram negative species Ralstonia solanacearum, Pseudomonas aeruginosa and Esherichia coli. The antifungal activity was tested against Aspergillus flavus, Fusarium and phoma. The biological results obtained suggest that the microbial growth inhibition was higher in the chloro based N-phenothiazine derivatives (3a-3c) than its morpholine derivative (5a-5c)....
In the present study, a novel series of 4-(2, 5-dimethyl-1H-pyrrol1-yl)-N'-(2-oxoindolin-3-ylidene) benzohydrazides have been synthesized in good yields and characterized by IR, NMR and mass spectral analyses. Compounds were evaluated for their preliminary in-vitro cytotoxic activity against HCT-116 (colon), MCF-7 (breast) and HepG2 (hepatocellular) cancer cell lines by standard MTT assay and also were screened for antioxidant activity standard DPPH assay method. Our results show that three of the analogues 7i, 7f and 7b are potent cytotoxic agents against all tumor cell lines assayed, showing significant IC50 values. The IC50 values of compounds 7i, 7f and 7b against MCF-7 were 32.07, 31.72, 34.25 μg/ml; against HCT-116 were 24.41, 21.25, 39.23 μg/ml and against HepG2 were 15.01, 29.23, 22.95 μg/ml, respectively, by comparing with positive control cisplatin (IC50 = 12. 18, = 23. 99 and =7. 23 μg/ml for HCT-116, MCF-7 and HepG2 respectively. Compound 7i was proved as potent antioxidant agent....
The transition metal complexes of Zn has been synthesized using 2-chloro phenothiazine derivatives as main ligand and purified by recrystallization in methanol. These products have been characterized based on their elemental analysis, molar conductance, UV, IR, mass, TGA, melting point and magnetic studies. All the metal complexes are mononuclear and have tetrahedral geometry. Synthesized metal complexes were screened for anti-microbial activity....
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